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Unprecedented Chain-Length-Dependent Conformational Conversion Between 11/9 and 18/16-Helix in /-Hybrid Peptides

Legrand, B. et al.

Angewandte Chemie. VOL 126; NUMBER 48, ; 2014, 13347-13351 -- John Wiley & Sons, Ltd Part 48; (pages 13347-13351) -- 2014

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  • Title:
    Unprecedented Chain-Length-Dependent Conformational Conversion Between 11/9 and 18/16-Helix in /-Hybrid Peptides
  • Author: Legrand, B.;
    Andr, C.;
    Moulat, L.;
    Wenger, E.;
    Didierjean, C.;
    Aubert, E.;
    Averlant-Petit, M. C.;
    Martinez, J.;
    Calmes, M.;
    Amblard, M.
  • Found In: Angewandte Chemie. VOL 126; NUMBER 48, ; 2014, 13347-13351
  • Journal Title: Angewandte Chemie.
  • Subjects: Biotechnology; Chemistry; Pharmaceutical Chemistry; LCC: QD1; Dewey: 540
  • Publication Details: John Wiley & Sons, Ltd
  • Language: English
  • Abstract: Abstract ,-Hybrid oligomers of varying lengths with alternating proteogenic -amino acid and the rigid 2,3,3-trisubstituted bicyclic amino acid ABOC residues were studied using both X-ray crystal and NMR solution structures. While only an 11/9-helix was obtained in the solid state regardless of the length of the oligomers, conformational polymorphism as a chain-length-dependent phenomenon was observed in solution. Consistent with DFT calculations, we established that short oligomers adopted an 11/9-helix, whereas an 18/16-helix was favored for longer oligomers in solution. A rapid interconversion between the 11/9-helix and the 18/16-helix occurred for oligomers of intermediate length.
  • Identifier: Journal ISSN: 0044-8249
  • Publication Date: 2014
  • Physical Description: Electronic
  • Accrual Information: Weekly
  • Shelfmark(s): 0902.000000
  • UIN: ETOCRN362973830

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