skip to main content
Show Results with:

Genetics and evolution of Yersinia pseudotuberculosis O-specific polysaccharides: a novel pattern of O-antigen diversity

Kenyon, Johanna J.; Cunneen, Monica M.; Reeves, Peter R.

FEMS microbiology reviews. Volume 41:Issue 2 (2016); pp 200-217 -- Oxford University Press

Online access

  • Title:
    Genetics and evolution of Yersinia pseudotuberculosis O-specific polysaccharides: a novel pattern of O-antigen diversity
  • Author: Kenyon, Johanna J.;
    Cunneen, Monica M.;
    Reeves, Peter R.
  • Found In: FEMS microbiology reviews. Volume 41:Issue 2 (2016); pp 200-217
  • Journal Title: FEMS microbiology reviews
  • Subjects: Microbiology--Periodicals; Microbiology--Reviews--Periodicals; Yersinia pseudotuberculosis--O antigen--O-specific polysaccharide--lipopolysaccharide--gene cluster--serotype; Dewey: 579.05
  • Rights: Licensed
  • Publication Details: Oxford University Press
  • Abstract: Abstract:

    O-antigen polysaccharide is a major immunogenic feature of the lipopolysaccharide of Gram-negative bacteria, and most species produce a large variety of forms that differ substantially from one another. There are 18 known O-antigen forms in the Yersinia pseudotuberculosis complex, which are typical in being composed of multiple copies of a short oligosaccharide called an O unit. The O-antigen gene clusters are located between the hemH and gsk genes, and are atypical as 15 of them are closely related, each having one of five downstream gene modules for alternative main-chain synthesis, and one of seven upstream modules for alternative side-branch sugar synthesis. As a result, many of the genes are in more than one gene cluster. The gene order in each module is such that, in general, the earlier a gene product functions in O-unit synthesis, the closer the gene is to the 5 ΄ end for side-branch modules or the 3 ΄ end for main-chain modules. We propose a model whereby natural selection could generate the observed pattern in gene order, a pattern that has also been observed in other species.

    O-antigen gene clusters in the Yersinia pseudotuberculosis complex.


  • Identifier: System Number: ETOCvdc_100075003069.0x000001; Journal ISSN: 0168-6445; 10.1093/femsre/fux002
  • Publication Date: 2016
  • Physical Description: Electronic
  • Shelfmark(s): 3905.305000
  • UIN: ETOCvdc_100075003069.0x000001

Searching Remote Databases, Please Wait