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Importance of protein flexibility in ranking inhibitor affinities: modeling the binding mechanisms of piperidine carboxamides as Type I1/2 ALK inhibitors1

Kong, Xiaotian et al.

Physical chemistry chemical physics. Volume 17:Issue 8 (2015); pp 6098-6113 -- Royal Society of Chemistry

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  • Title:
    Importance of protein flexibility in ranking inhibitor affinities: modeling the binding mechanisms of piperidine carboxamides as Type I1/2 ALK inhibitors1
  • Author: Kong, Xiaotian;
    Pan, Peichen;
    Li, Dan;
    Tian, Sheng;
    Li, Youyong;
    Hou, Tingjun
  • Found In: Physical chemistry chemical physics. Volume 17:Issue 8 (2015); pp 6098-6113
  • Journal Title: Physical chemistry chemical physics
  • Subjects: Chemistry, Physical and theoretical--Periodicals; Dewey: 541.3
  • Rights: legaldeposit
  • Publication Details: Royal Society of Chemistry
  • Abstract: <x xml:space="preserve">Abstract</x>

    Anaplastic lymphoma kinase (ALK) has gained increased attention as an attractive therapeutic target for the treatment of various cancers, especially non-small-cell lung cancer (NSCLC).


  • Identifier: ETOClsidyv9219f053; System Number: LDEAvdc_100026011548.0x000001; Journal ISSN: 1463-9076; 10.1039/c4cp05440g
  • Publication Date: 2015
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store

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